STM Article Repository

Dighriri, Ibrahim and Mobarki, Ahmed and Althomali, Naif and Alqurashi, Khalid and Daghriri, Othman and Howimel, Bashaer Bin and Alahmad, Izdihar and Alsaadi, Rawan and Alsufyani, Manar and Balobade, Manar and Altemani, Reem and Alatawi, Bayader and Sharoufna, Wejdan and Almuntashiri, Taif and Almushawwah, Sultan (2021) Detect Drug Interactions with Metronidazole. Journal of Pharmaceutical Research International, 33 (47A). pp. 597-604. ISSN 2456-9119

[thumbnail of 3860-Article Text-5666-1-10-20221006.pdf] Text
3860-Article Text-5666-1-10-20221006.pdf - Published Version

Download (329kB)

Abstract

Introduction: Metronidazole has been prescribed to treat infections for over a century and continues to be helpful in the therapy of amoebiasis, trichomoniasis, and giardiasis. Metronidazole is a cost-effective medication because of its low price, few adverse effects, and favorable pharmacokinetic and pharmacodynamic properties; nevertheless, it interacts with a wide variety of other medications. Some interactions with other medicines diminish its effectiveness, while others increase it.

Aims: The study aims to detect and evaluate metronidazole interactions with other medicines at King Abdulaziz Specialist Hospital.

Methodology: This retrospective study encompasses the review of 360 computerized prescriptions inside the outpatient clinic at King Abdulaziz Specialist Hospital in Saudi Arabia between March and September 2020 to detect and evaluate interactions among metronidazole and different medications.

Results: Metronidazole interactions are mostly major or moderate. Metronidazole had the most common interactions with domperidone (15.83 %), famotidine (13.89 %), and ciprofloxacin (11.67 %). Metronidazole contains a nitroimidazole ring, which suppresses the metabolism in the liver of numerous medications, including those that may be metabolized by the CYP3A4 and/or CYP450 2C9 isoenzymes. The combination of metronidazole with phenytoin or phenobarbital can cause metronidazole elimination to be accelerated and phenytoin clearance to be reduced. Metronidazole may improve warfarin's anticoagulant effects, leading to a longer prothrombin time and a higher risk of bleeding. Concurrent use of metronidazole with alfuzosin, escitalopram, and ondansetron may raise the risks of QT-interval prolongation and arrhythmias.

Conclusion: Most metronidazole drug interactions can be avoided by following excellent clinical care and clinical pharmacology concepts, such as avoiding complex treatment regimens, educating patients. and identifying patient risk factors. Furthermore, before prescribing and dispensing medicines, physicians and pharmacists should utilize drug-drug interactions checkers such as Micromedex and Lexicomp or a book such as Stockley's Drug Interactions.

Item Type: Article
Subjects: GO for ARCHIVE > Medical Science
Depositing User: Unnamed user with email support@goforarchive.com
Date Deposited: 06 Mar 2023 09:42
Last Modified: 09 Feb 2024 04:02
URI: http://eprints.go4mailburst.com/id/eprint/65

Actions (login required)

View Item
View Item