STM Article Repository

Maghsoodi, Maryam and Montazam, Seyed hassan and Rezvantalab, Hossein and Jelvehgari, Mitra (2020) Response Surface Methodology for Optimization of Process Variables of Atorvastatin Suspension Preparation by Microprecipitation Method Using Desirability Function. Pharmaceutical Sciences, 26 (1). pp. 61-74. ISSN 1735-403X

[thumbnail of ps-26-61.pdf] Text
ps-26-61.pdf - Published Version

Download (1MB)

Abstract

Background: Atorvastatin (AT), as a synthetic lipid-lowering agent, is a highly crystalline substance having poor solubility and low bioavailability. The objective of the present research was to improve the microprecipitation method of AT suspension preparation.

Methods: Microprecipitation parameters were improved using Box-Behnken experimental design method. The suspension was formulated with Brij 35 (stabilizer agent) using methanol as solvent and water as non-solvent, respectively. DSC, XRD, FTIR studies were performed for characterization of the microcrystals. With the aim of evaluating the effect of independent variables, the amounts of organic solvent (X1), emulsifier concentration (X2), stirring rate (X3), and volume of aqueous solvent (X4) on dependent variables, drug content (DC,) particle size (PS), drug released after 5 minutes (Q5), Gibbs free energy change (ΔG°tr), crystal yield (CY) and saturated solubility (Ss), a full factorial was used.

Results: The results of DSC, XRD, and FTIR showed that there was not any interaction between AT and Brij 35. This research demonstrated a reduction in crystallinity in agglomerates. The microcrystals showed that micromeritics characteristics were significantly improved compared to pure AT. The content of drug and yield crystal was in the limit of 42.58-110.24% and 58.33-98.18% in all formulations, respectively. It was shown that the prepared microcrystals had a higher rate of release compared to the untreated AT powder (P< 0.05). Size reduction of AT is needed for improving the solubility. Solubility and drug release rates of At was enhanced with the microprecipitation method.

Conclusion: The results showed that microcrystals significantly increased AT dissolution rate.

Item Type: Article
Subjects: GO for ARCHIVE > Medical Science
Depositing User: Unnamed user with email support@goforarchive.com
Date Deposited: 12 May 2023 06:32
Last Modified: 02 Nov 2023 06:15
URI: http://eprints.go4mailburst.com/id/eprint/811

Actions (login required)

View Item
View Item