Rurik, Joel G. and Tombácz, István and Yadegari, Amir and Fernández, Pedro O. Méndez and Shewale, Swapnil V. and Li, Li and Kimura, Toru and Soliman, Ousamah Younoss and Papp, Tyler E. and Tam, Ying K. and Mui, Barbara L. and Albelda, Steven M. and Puré, Ellen and June, Carl H. and Aghajanian, Haig and Weissman, Drew and Parhiz, Hamideh and Epstein, Jonathan A. (2023) CAR T Cells Produced in vivo to Treat Cardiac Injury. B P International, pp. 240-249. ISBN 978-81-19039-65-4
Full text not available from this repository.Abstract
Fibrosis affects millions of people with cardiac disease. We developed a therapeutic approach to generate transient antifibrotic chimeric antigen receptor (CAR) T cells in vivo by delivering modified messenger RNA (mRNA) in T cell–targeted lipid nanoparticles (LNPs). The efficacy of these in vivo–reprogrammed CAR T cells was evaluated by injecting CD5-targeted LNPs into a mouse model of heart failure. Efficient delivery of modified mRNA encoding the CAR to T lymphocytes was observed, which produced transient, effective CAR T cells in vivo. Antifibrotic CAR T cells exhibited trogocytosis and retained the target antigen as they accumulated in the spleen. Treatment with modified mRNA-targeted LNPs reduced fibrosis and restored cardiac function after injury. In vivo generation of CAR T cells may hold promise as a therapeutic platform to treat various diseases.
| Item Type: | Book |
|---|---|
| Subjects: | GO for ARCHIVE > Medical Science |
| Depositing User: | Unnamed user with email support@goforarchive.com |
| Date Deposited: | 02 Oct 2023 09:23 |
| Last Modified: | 02 Oct 2023 09:23 |
| URI: | http://eprints.go4mailburst.com/id/eprint/1234 |
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