STM Article Repository

The synthesis of antitumor active compounds is a major focus of interest in many research groups in the world. We want to offer less toxic and more effective treatments. Today, the attention of the scientific community is focused on agents, that are more natural. The molecule PHCUMN1 (a derivative of heteroaromatic amino acid complexes), displays activity against cancer cells. The mechanism of anticancer was investigated responsible for this medicament in cells of breast cancer (in vitro testing). PHCUMN is responsible for a dose-dependent decrease and unattached growth of cancer cells MCF-7. We investigated the anti-proliferative potential of PHCUMN in breast cancer cell lines. It also clarified the mechanism of action of PHCUMN in preclinical models of breast cancer. We investigated the anti proliferative ability of PHCUMN against cancer cell. We wanted to elucidate the mechanism and potency of PHCUMN in preclinical studies on cancer cell. PHCUMN has been shown to have a good effect in killing cancer cell. The percentage fragmentation laterally shows the destruction of cancer cell. PHCUMN showed good efficacy in killing cancer cells. This is done without a visible influence on normal cancer cells the percentage of Fragmentation and nuclear shrinkage clearly shows the apoptosis of tumor cells. According to mentioned results, we can draw conclusion that PHCUMN has potential to effect against cancer cell. The intermolecular electrostatic interaction between the side chains of DNA nucleobases with PHCUMN – stabilized the complex. The complex PHCUMN has been evaluated from the following equilibrium: DNA+ PHCUMN DNA-PHCUMN , which lies predominantly on the right site.