STM Article Repository

This paper presents a case of generalized advanced periodontal destruction of the permanent and deciduous dentition in a 9-year old Iranian girl with a severe phenotype of LAD-I. LAD is a rare autosomal recessive disorder characterized by immunodeficiency resulting in recurrent infections. LAD is currently divided into three subtypes: LADI, LADII, and LADIII. The most common type is LADI. LAD I is due to structural defects in the integrin molecule, preventing firm adhesion to occur. Affected patients are susceptible to recurrent bacterial and fungal infections, delayed wound healing, and periodontitis. The present case report emphasizes the importance of the differential diagnosis of severe immunodeficiency disorders in children and adolescents and mandates the importance of combined care by medical and dental practitioners to prevent tooth loss and control oral infection.