CHERNYSHENKO, V. O. and PIROGOVA, L. V. and DIDKIVSKYI, V. A. and CHERENOK, S. O. and DOSENKO, V. Е. and PASHEVIN, D. O. and KALCHENKO, V. I. and MAKOGONENKO, E. M. and LUGOVSKOY, E. V. (2016) EFFECTS OF Calix[4]arene C-145 ON OVERALL HAEMOSTATIC POTENTIAL OF BLOOD PLASMA In vitro AND In vivo. Journal of International Research in Medical and Pharmaceutical Sciences, 10 (3). pp. 146-151.
Full text not available from this repository.Abstract
Introduction: The overall haemostatic potential (OHP) assay was applied for testing of anticoagulant action of sodium salt of calix[4]arenemethylene-bis-phosphonic acid (C-145) in blood plasma In vitro and In vivo.
Methods: Calix[4]arene C-145 was added to platelet poor plasma or injected intravenously to rabbits in equal concentrations (20 µM), clotting was initiated by APTT-reagent and turbidity change of the mixture was measured in the presence or absence of tPA.
Results: We demonstrated that in vitro 20 μM of C-145 substantially decreased the OHP in 1.5 times and did not influence fibrinolysis. That injection of calix[4]arene in vivo decreased the overall haemostatic potential in 30-10%. The prolongation of half-time of clot lysis was not observed.
Conclusion: Overall haemostatic potential assay allowed us to conclude that coagulation and fibrinolytic branches of haemostasis remain in dynamic balance at C-145 administration. C-145 being taken in the final concentration 20 μM inhibited coagulation potential of blood plasma and did not affect fibrinolysis in vivo.
| Item Type: | Article |
|---|---|
| Subjects: | GO for ARCHIVE > Medical Science |
| Depositing User: | Unnamed user with email support@goforarchive.com |
| Date Deposited: | 02 Dec 2023 05:43 |
| Last Modified: | 02 Dec 2023 05:43 |
| URI: | http://eprints.go4mailburst.com/id/eprint/1853 |
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