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Background: Hypothyroidism can be understood and assessed on the basis of Agni, Doshas, Dushyas, Sthanas and Srotasas. In Ayurveda Vamana and Virechana Karma is considering as best line of Shodana procedures for the removal of toxin materials from the human body. Hypothyroidism occurs because of hypo functioning of thyroid gland which is located in neck region and even most of the signs and symptoms prove the involvement of Kapha Sthana and Kapha Dosha. So, in the present clinical research, Vamana and Virechana karma of Panchkarama will be selected as clinical tool to check its impact on Hypothyroidism (Galaganda).

Aim and Objectives: To explore Vamana & Virechana Karma regarding their Clinical Importance. To validate Vamana & Virechana Karma as an effective mode of treatment in the management of Hypothyroidism.

Methodology: 90 (45 in each group) patients will be selected by randomized reference standard controlled single blind double arm clinical trial, and third party will assign and enlist the patient. In Group A (Control) – Standard/ Control Group treated with Thyroxin and Group B (Experimental) – Intervention Group treated with Vamana and Virechana Karma. The evaluation will be recorded on 0 30, 60, 90, 120, 150, 180 days.

Results: Changes will be observed in objective outcomes.

Conclusion: Vamana and Virechana will be effective in Hypothyroidism.