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The study was conducted in the Sagnarigu Municipality in Northern Ghana to assess sheep fattening practices and marketing systems. Eighty respondents were selected and questionnaires administrated to them. Data was summarized and analysed using SPSS version 20. Majority of the fatteners were within the ages 21-30 years. Sheep fatteners were not equally distributed across the different age groups. Most of the farmers had at least primary education while majority (30.0%) of them had tertiary education. The sheep fattening enterprise in the area was male and Muslim dominant activity. Majority of respondents were engaged in specialized skill work as their main occupation with self-financing as the main source of income for the sheep fattening business. Majority had at most 5 years fattening experience. Semi-intensive system of management was mainly practiced. Farmers use wide range of feed stuff alternatively and supplied from multiple sources. Mature animals (≥ 6 months) sourced from farmers’ own flock were mostly used in fattening. Generating cash was the primary motivation for fattening sheep, with a convenient market for the fattened sheep. Customers of fattened sheep were mainly butchers. mostly at local markets (50%). Price determination for the fattened sheep was bargaining. The major constraints of sheep fatteners were diseases and mortality and lack of capital/financial. It was concluded that sheep fattening practices and marketing system was a business in the Sagnarigu municipality, nevertheless, it was not well organized and developed. To create a lucrative sheep fattening industry, government and non-governmental organizations should promote sheep fattening by providing financial and training support for the fatteners and the teaming youth in Ghana to venture into the business. This could contribute to enhancing livelihood of rural resource poor farmers, unemployment and poverty reduction as well as women empowerment in the country.