STM Article Repository

The study shows some changes in prooxidant-antioxidant systems both in the bile and blood in patients with obstructive jaundice. Among the indicators of antioxidant defense the greatest increase in activity was observed in catalase (by 4,5-5,1 times) and superoxide dismutase (by 13,1-16,3 times) in the bile in the development of cholangitis. Significant violations have also been revealed at the local and systemic level in the low-molecular activity of the antioxidant system, which were compensatory in choledocholithiasis and were manifested by increasing plasma (57,9%) and bile (8,2%) antioxidant activity. In addition, intensification of free radical oxidation has been marked which was revealed in the blood plasma in malignancy of biliopankreatoduodenal zone (3,0 times), reflecting regulatory changes at the system level. A more frequent use of bile for diagnosis also allows its more adequate monitoring the status of patients with obstructive jaundice due to the comprehensive analysis of local prooxidant-antioxidant system indicators.