Gholipour, Naghmeh and Akbarian, Fatemeh and Khajeh, Hamideh and Ghahhari, Sajjad and Samaei, Nader Mansour (2018) Mutational Screening of the Negative Regulatory Region of Astrocyte Elevated Gene -1 Promoter in Hepatocellular Carcinoma Patients. Journal of Scientific Research and Reports, 20 (6). pp. 1-7. ISSN 23200227
![[thumbnail of Samaei2062014JSRR10085.pdf]](http://eprints.go4mailburst.com/style/images/fileicons/text.png)
Text
Samaei2062014JSRR10085.pdf - Published Version
Download (255kB)
Abstract
Objective: This study is aimed to assess the correlation between negative regulatory region of AEG-1 promoter and genetic susceptibility to hepatocellular carcinoma in Iranian population.
Methods: The negative regulatory region of human AEG-1 promoter was explored in 50 Iranian HCC patients. The PCR-sequencing method was used for investigating AEG-1 promoter polymorphisms.
Results: This analysis did not reveal the presence of any deletions, insertions, or mutations in this region ofAEG-1 promoter.
Conclusion: Mutations in the negative regulatory region of AEG-1 promoter have no significant relevance with hepatocellular carcinoma. Nevertheless, to our knowledge, this is the first study to investigate the mutations of the negative regulatory region of AEG-1 promoter in HCC patient. The role of AEG-1 promoter played in HCC needs to be further studied.
| Item Type: | Article |
|---|---|
| Subjects: | GO for ARCHIVE > Multidisciplinary |
| Depositing User: | Unnamed user with email support@goforarchive.com |
| Date Deposited: | 03 May 2023 06:07 |
| Last Modified: | 29 Jan 2024 06:14 |
| URI: | http://eprints.go4mailburst.com/id/eprint/613 |
Actions (login required)
- View Item