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jAims: Here, we analyse biofilm formation in relation to multiple drug resistance among nosocomial isolates of Escherichia coli.

Study Design: Randomized study design.

Place and Duration of Study: The study was a cross sectional study conducted at the Department of Microbiology, University of Maiduguri, Nigeria, from April 2018 to May 2018.

Methodology: Ten (10) clinical isolates were collected and confirmed using standard bacteriological methodology. Congo Red Agar (CRA) was used to analyse biofilm formation among isolates. Antimicrobial susceptibility test was done using Kirby bauer disc diffusion test, where the efficacy of ten (10) selected drugs against the isolates was examined.

Results: Seventy percent (70.0%) of the isolates were found to produce biofilm. All isolates were resistant to Ofloxacin (100%; f=4.5, P<0.01). 57.1% of the biofilm producing isolates were observed to be multi drug resistant. Biofilm-producing/multi-drug resistant isolates were resistant to an average of ninety five percent (95.0%) of antimicrobial drugs tested. Fourty three percent (43.0%) of the biofilm producing phenotypes were Pandrug resistant.

Conclusion: In view of this, it is can be deduced that there is a relationship between biofilm formation and multiple drug resistance among nosocomial isolates of Escherichia coli.