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Tra-Bi, Irie Otis and Djyh, Bernard Nazaire and Coulibaly, Amadou Founzegue and Djaman, Allico Joseph and N’guessan, Jean David (2013) Cardiac Tolerance Study of Morinda morindoides (Baker) Milne-Redhead (Rubiaceae) Extract in Rabbit. International Journal of Biochemistry Research & Review, 3 (4). pp. 291-302. ISSN 2231086X

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Abstract

Purpose: This study was conducted to assess the effect of the ethyl acetate fraction (AcEF1) obtained from the 96% extract of Morinda morindoides extract on cardiac tissue integrity and function in rabbits.

Methodology: The rabbits were divided in five groups of 6 rabbits each. Groups 2,3,4 and 5 received intraperitoneally, twice a week during four weeks, the ethyl acetate fraction at doses going from 25 to 100 μg/kg body weight while Group 1, received 1 mL of Mac Ewen fluid. Blood sampling was carried out to evaluate aspartate aminotransferase (AST), alanine aminotransferase (ALT), Creatine phosphokinase (CPK), Lactate dehydrogenase (LDH) activities and level of calcium, sodium, potassium, magnesium and chloride in serum. The eighth week of the experiments, histopathological studies were also conducted on rabbits heart.

Results: Analysis of the serum markers showed slight increases in AST, ALT, CPK activities as well as sodium, calcium and potassium concentrations (p<0.05). LDH activity, magnesium and chloride concentrations were unchanged compared to their initial values.

Histopathological studies had not revealed damages in the structure of the heart.

Conclusion: The ethyl acetate fraction did not exert any noxious effect on cardiac tissues and should be no toxic for cardiac tissues.

Item Type: Article
Subjects: GO for ARCHIVE > Social Sciences and Humanities
Depositing User: Unnamed user with email support@goforarchive.com
Date Deposited: 29 Jun 2023 03:55
Last Modified: 16 Oct 2023 04:00
URI: http://eprints.go4mailburst.com/id/eprint/973

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